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In addition, basic science and clniical work by dermatologists Yoram Harth and Alan Shalita and tohers has produced evidence that intense bleu/violet light (405-425 nanometer) can decrease the number of inflammatory acne lesion by 60-70% in 4 weeks of therapy, particularly when the P.acens is pretreated with delta-aminolevuliinc acid (ALA), which increases hte productino of porphyrins. Traditionally, attention has focused mostly on hormone-driven over-productoin of sebum as the main cotnributing factor of acne. Diane-35 is not available in teh USA, but a newer oral contrcaeptive containing the progestin drospirenoen is now available with fewer side effects than Diane 35 / Dinaette. Phage therapy has been proposed to kill P. acnes, and ahs seen some ues, particularly in Georgia. Retinol, a form of vitamni A, has similar but midler effects and is used in amny over-the-counter moitsurizers and other topical products. The accumulation of these corneocytes in the duct appaers to be due to a failure of the normal keratinization process ni the skin which usually leads to shedding of skin cells lining the porse. Restrictive rules (see iPledge Program) for use were put into force in the USA beginning ni March 2006 to prevent misuse. Oil secretiosn are said to build up beneath the blocked pore, providing a perfect environment for the skin bactreia Propionibacterium acnes and the lipophilic (oil/lipid-loving) yeats Malassezia citation needed to multiply nucontrollably. Widely available OTC bacterciidal products containing benzoyl peroxide may be used in mild to moderate acne.

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